Cystic fibrosis (CF) is a recurrent autosomal recessive disorder affecting approximately 70,000 people worldwide. The disorder is caused by mutation in the CF transmembrane conductance regulator (CFTR) gene on chromosome 7. The target population with Cystic Fibrosis are of Caucasian descent, therefore the disease is most prevalent in North America, Europe, and Australasia. However, Cystic Fibrosis can affect nearly every race and ethnicity, including African, Latin American, and Middle Eastern populations.
Here are the statistics of Cystic Fibrosis:
- Caucasians- 1 case per 3,200-3,500 people
- Hispanics- 1 case per 9,200-9,500 people
- African Americans- 1 case per 15,000-17,000 people
- Asian Americans- 1 case per 31,000 population
Genetics of Cystic Fibrosis
People with CF have inherited two copies of the defective CF gene - one copy from each parent. Both parents must have at least one copy of the defective gene.
People with only one copy of the defective CF gene are called carriers, but they do not have the disease. Each time two CF carriers have a child, the chances are: 25 percent (1 in 4) the child will have CF, 50 percent (1 in 2) the child will be a carrier but will not have CF. 25 percent (1 in 4) the child will not be a carrier and will not have CF. Each year there are 1,000 new diagnosed cases of Cystic Fibrosis; 75 percent of diagnosed persons having been diagnosed since age 2.
Known Ethnicity factors of Cystic Fibrosis
The clinical manifestations of Cystic Fibrosis are similar in black and white populations, except most commonly in black populations, they have lower quality of nutritional status. This deficiency influences the age at which they develop Cystic Fibrosis (usually begins at a younger age) and decreases their overall pulmonary function.
Known Sex factors of Cystic Fibrosis
Women who develop Cystic Fibrosis have a greater decline in pulmonary function as compared to men. The cause behind this is not completely understood or known, but it has been attributed to hormone secretion during puberty in females that may interfere with the defense mechanisms of the immune system. This promotes opportunistic infections within the pulmonary system in conjunction with decreased pulmonary function due to Cystic Fibrosis.
https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/
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